Endocrine Abstracts

Cancer registers are important tools in improving the knowledge of epidemiology of rare malignancies, such as gastro-entero-pancreatic neuroendocrine tumors.Aim: To assess the epidemiology of GEPNETs in Krakow and Krakow district area between January 2007 and December 2011.Material and methods: To assess the epidemiology of GEPNETs in Krakow area a register was created, based on independent sources of information. 88 patients (49 f...

Abstract Identification of factors influencing survival of the gastro-entero-pancreatic neuroendocrine tumors patients may improve their management by better selection of subjects requiring more closed follow-up and more aggressive therapeutic approach.Aim: To assess factors influencing survival of GEPNET patients livingin Krakow and Krakow district area.Material and methods: The data from GEPNETs register run in t...

Cushing’s syndrome caused by ectopic ACTH secretion (EAS) constitutes ~10% of Cushing’s syndrome (CS).The aim of this study was to present experience of our Clinic with EAS.).Patients: Twelve patients, aged 14–70 years: four females and eight males.Outcomes and measurements: Clinical features, medical examination, morning electrolytes, glucose level, serum cortisol, ACTH levels, midnight plasma...

Introduction: The aim of this study was to assess the efficacy of peptide receptor radionuclide therapy (PRRT) with the use of 90Y-DOTATATE and the survival rate of patients with disseminated or non-operable neuroendocrine tumors (NETs).Methods: In the time period from June 2006 to October 2012, 70 patients were treated with PRRT in our department. The 90Y-DOTATATE therapeutic activity was calculated per total body surface area up t...

Introduction: In accordance with a rising number of pregnant women with thyroid gland dysfunctions, The Thyroid Gland’s Disorders Outpatient Clinic for Pregnant Women has started its activity in our Endocrinology Department in January 2008. Patients with or without thyroid gland dysfunction in history have been under medical care.During pregnancy thyroid gland is prone to the number of physiological changes, which cause difficulties in the interpret...

The incidence of gastric neuroendocrine tumors (GNT) is increasing, what can be explained by the increased detection caused by the common use of the endoscopy and the pervasive use of acid suppressive therapy leading to enterochromatofine like cells proliferation. There are numerous new diagnostic/therapeutic GNT methods in use like: EUS, SRS, somatostatin therapy and 90Y/177Lu-DOTA-TATE radiotherapy.Materials and methods: In 1998–2008 37 patients w...

Background: Multiple endocrine neoplasia syndrome type 2 (MEN2) is a rare disease characterised by inherence in each patient medullary thyroid carcinoma (MTC), pheochromocytoma and in type MEN 2a primary hyperparathyroidism, in type MEN2b marfanoid habitus and neurofibromas. Mutation in RET proto-oncogene at chromosome 10 is a molecular cause of MEN2 syndrome.Methods: Eighteeen patients with MEN2 syndrome were enrolled: (10 women and 8 men) mean age 22&#...

Background: NETs are rare tumours arising from dispersed neuroendocrine system. Nevertheless, their estimated prevalence increased lately, mostly due to progress in imaging, biochemical and histopathological diagnostics.The aim of the study was to present the characteristics of the NETs patient surveyed in our Endocrinology Department since 2000.Material and methods: One hundred and fifty-eight patients (males – 42.4%, females...

Introduction: Neuroendocrine tumors secreting ACTH are a rare cause of Cushing’s syndrome.Diagnostic and therapeutical difficiulties might be caused due to different clinical picture of of neuroendocrine tumors.Patients, diagnostic and therapeutic approach: During 2004–2005 2 female patients 32-years old AL and 67-years old ZS were hospitalized in Endocrinology Department due to severe hypercorticism signs and symptoms. I...

Introduction: Measurement of the baseline level of 17-hydroxyprogesterone (17OHP) is a screening test for NCAH, a less severe form of congenital adrenal hyperplasia.Aim: A real-life verification of the currently adopted 17OHP threshold (≥2.0 ng/ml) at which the further diagnostic (cosyntropin stimulation test) should be performed.Material and methods: The study included 400 patients (385 females and 15 males) referred to the ...